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Predicting pharmacokinetic behaviour of compounds from structure and physicochemical information
Reference
MOL04617
Principal Investigator / Supervisor
Professor Malcolm Rowland
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Manchester Pharmacy School
Funding type
Research
Value (£)
117,244
Status
Completed
Type
Research Grant
Start date
20/03/1996
End date
20/03/1999
Duration
36 months
Abstract
Combinatorial chemistry and high throughput biological target screens rapidly generate many potentially bioactive molecules, from which only some must be selected for the subsequent more demanding and expensive in vivo evaluation. The possibility of aiding early drug selection by predicting likely changes in pharmacokinetics in tissues and plasma directly from chemical structure is to be explored experimentally in rat with a series of structurally related compounds, within the context of a physiologically-based model.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Molecules (Ropa) (MOL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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