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Pharmacokinetics of antisense oligonucleotides
Reference
MOL04615
Principal Investigator / Supervisor
Professor Malcolm Rowland
Co-Investigators /
Co-Supervisors
Institution
The University of Manchester
Department
Manchester Pharmacy School
Funding type
Research
Value (£)
100,700
Status
Completed
Type
Research Grant
Start date
04/12/1995
End date
04/12/1998
Duration
36 months
Abstract
A strategy is proposed to develop a quantitative framework for defining the pharmacokinetics of oligonucleotides in vivo. Using specific assays, a physiologically-based approach will be taken to characterise and model the pharmacokinetics of oligonucleotides in plasma and tissues after single and multiple administration to mice and rats. Detailed kinetic aspects of hepatic uptake and distribution will be explored in the isolated perfused liver.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Molecules (Ropa) (MOL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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