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Engineering insecticidal toxins
Reference
MOL04590
Principal Investigator / Supervisor
Professor Colin Berry
Co-Investigators /
Co-Supervisors
Institution
Cardiff University
Department
School of Biosciences
Funding type
Research
Value (£)
81,796
Status
Completed
Type
Research Grant
Start date
01/12/1995
End date
01/12/1997
Duration
24 months
Abstract
Sequence comparisons of the binary toxins isolated from different strains of Bacillus sphaericus reveal a relatively small number of amino acid changes. However, these are sufficient to produce distinct differences in the ability of the proteins to kill the larvae of various mosquito species. The sequences responsible for activity against Aedes aegypti have been established by the construction of a series of chimeric toxins. Further enhancement of toxicity is feasible and a design-based programme to produce novel toxin sequences for maximum activity against the widest range of mosquitoes is proposed.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Molecules (Ropa) (MOL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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