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The fundamental function of phosphatidylinositol (345) trisphosphate
Reference
MOL04583
Principal Investigator / Supervisor
Professor Andrew Holmes
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Chemistry
Funding type
Research
Value (£)
156,670
Status
Completed
Type
Research Grant
Start date
04/04/1996
End date
30/09/1999
Duration
42 months
Abstract
A versatile synthetic route in inositol chemistry will be developed in Cambridge to make available a range of all the natural and enantiomeric phosphoinositides and some analogues. The materials will be designed to provide important answers in the biological pathways involving phosphoinositides. The new materials will be evaluated in a collaborative programme with the intracellular signalling group led by Dr L R Stephens at Babraham. In particular the function of these materials will be explored under the following headings : (a) Caged PtdIns[3,4,5]P3; (b) Immobilised PTdIns[3,4,5]P3; (c) 5-Phosphothionate analogues; (d) Tritiated derivatives; (e) Photoaffinity reagents.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Molecules (Ropa) (MOL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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