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Novel approaches to squalene biosynthesis and to controls of branch-points of isopentenoid metabolism
Reference
MOL04571
Principal Investigator / Supervisor
Dr Geoffrey Hazlewood
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
138,339
Status
Completed
Type
Research Grant
Start date
01/08/1995
End date
01/08/1998
Duration
36 months
Abstract
We propose to generate strains and mutants of yeast to investigate the controls of mevalonate metabolism at branch-points leading to the formation of squalene, ubiquinone, carotenoids, dolichols or prenylating compounds. To this end, we shall generate sterol auxotrophs of yeast which are deficient in squalene epoxidase or other enzymes of isopentenoid metabolic pathways, and which possess elevated levels of hydroxymethyl glutaryl CoA reductase activity.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Molecules (Ropa) (MOL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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