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Supercharged nucleotide analogues: synthesis and biological applications
Reference
MOL04558
Principal Investigator / Supervisor
Professor Michael Blackburn
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Chemistry
Funding type
Research
Value (£)
149,357
Status
Completed
Type
Research Grant
Start date
09/10/1995
End date
09/10/1998
Duration
36 months
Abstract
Chemistry. We will make analogues of nucleotides having additional negative charge and stable to degradation by phosphatases. These will be based on the recently described methanetrisphosphonic acid and on its novel C-fluoro, C-hydroxy, and C-amino derivatives, to be synthesised in this work. Biochemistry. These analogues will be used to study reactions of nucleotide-using enzymes, especially ATP and dATP, and to generate transition state analogues of kinase processes, especially for adenylate kinase (EC 2.7.4.3) and phosphoglycerate kinase (EC 2.7.2.3).
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Molecules (Ropa) (MOL) [1994]
Funding Scheme
X – not Funded via a specific Funding Scheme
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