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Mathematical modelling of quorum sensing and other biological events leading to a Pseudomonas aeruginosa infection

Reference	MMI09757
Principal Investigator / Supervisor	Professor John King
Co-Investigators / Co-Supervisors	Professor Renee Sockett, Professor Paul Williams
Institution	University of Nottingham
Department	Sch of Mathematical Sciences
Funding type	Research
Value (£)	192,961
Status	Completed
Type	Research Grant
Start date	01/06/1999
End date	01/06/2002
Duration	36 months

Abstract

The pathogenesis of Pseudomonas aeruginosa infections will be investigated using a combination of mathematical models and in vitro experiments. Infection is viewed as a three stage process: 1) bacterial motility leading to surface adhesion and colonisation; 2) proliferation and quorum sensing leading to 3) release of exoproduct virulence determinants and infiltration into the host tissues. A continuum approach to the modelling will be adopted, forming a system of non-linear partial differential equations, with appropriate kinetic terms being determined from our experiments. This work aims to make possible extrapolation for in vitro studies to give genuine insight into the events in vitro and to provide the framework for simulation of various therapeutic strategies.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Mathematical Modelling Initiative (MMI) [1997]
Funding Scheme	X – not Funded via a specific Funding Scheme

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