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Mathematical modelling of autocrine cytokine networks

Reference	MMI09754
Principal Investigator / Supervisor	Professor Robert Marshall Seymour
Co-Investigators / Co-Supervisors	Professor Brian Henderson
Institution	University College London
Department	Mathematics
Funding type	Research
Value (£)	145,494
Status	Completed
Type	Research Grant
Start date	01/09/1998
End date	01/09/2001
Duration	36 months

Abstract

Cytokines are a large group of proteins which both integrate local homeostatic cell interactions and are major mediators of human disease. Cytokines interact with cells in a complex manner which has been defined as 'cytokine networks.' The complexity of these networks is such that cytokine biologists are, increasingly, unable to develop predictive and testable hypotheses to explain the actions and interactions of cytokines. Mathematical modelling is proposed as a way out of this impasse. We aim to build mathematical models, analyse them theoretically, and test them experimentally in in vitro single cell culture in an integrated programme to investigate dynamic, stochastic and spatial characteristics of such networks.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Mathematical Modelling Initiative (MMI) [1997]
Funding Scheme	X – not Funded via a specific Funding Scheme

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