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Mathematical modelling of spatio-temporal heterogeneity in mammalian and invertebrate cytokine signalling

Reference	MMI09729
Principal Investigator / Supervisor	Professor Christopher Cannings
Co-Investigators / Co-Supervisors	Professor Steven Dower, Professor Gordon William Duff, Professor Philip Ingham
Institution	University of Sheffield
Department	Mathematics and Statistics
Funding type	Research
Value (£)	136,837
Status	Completed
Type	Research Grant
Start date	01/10/1998
End date	01/10/2001
Duration	36 months

Abstract

All cells exhibit intracellular heterogeneity, which can be relatively stable or dynamic. Recent experiments have highlighted the central role of heterogeneity in cell response to external signals. Our broad aim is to investigate the nature and role of dynamic intracellular heterogeneity in response to cytokine signalling using a variety of mathematical models. Close collaboration with leading laboratories studying cell signalling in both Drosophila systems and mammalian systems is an essential part of the study. Data will inform the modelling; modelling will inform the experiments. The mathematical modelling requires new approaches as the classical spatially continuous models do not capture the essence of cellular entities. (Joint grant with 88/MMI09738)

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Mathematical Modelling Initiative (MMI) [1997]
Funding Scheme	X – not Funded via a specific Funding Scheme

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