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The coalescent process in genetically structured populations: measurement of selection from DNA sequence variation

Reference	MMI09726
Principal Investigator / Supervisor	Professor Nicholas Barton
Co-Investigators / Co-Supervisors	Professor Brian Charlesworth, Professor Deborah Charlesworth, Professor Alison Etheridge
Institution	University of Edinburgh
Department	Inst of Cell, Animal and Population Biol
Funding type	Research
Value (£)	110,184
Status	Completed
Type	Research Grant
Start date	01/03/1999
End date	01/03/2002
Duration	36 months

Abstract

We propose to apply methods for analysing systems with very many genes, and for approximating branching processes in spaces of high dimension, to genealogies in structured populations. This will allow proper interpretation of the information in populations of DNA sequences. Our aims are (a) to represent genealogies of samples of genes which are embedded in a complex genetic background; (b) to find tractable approximations for the case where there are very many gene combinations, which fluctuate in frequency; and (c) to develop statistical tests which can distinguish and measure various different modes of selection.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Mathematical Modelling Initiative (MMI) [1997]
Funding Scheme	X – not Funded via a specific Funding Scheme

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