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Stochastic models for the immuno-epidemiology and population genetics of macroparasites in farmed ruminants

Reference	MMI09026
Principal Investigator / Supervisor	Professor Bryan Grenfell
Co-Investigators / Co-Supervisors	Professor Valerie Isham
Institution	University of Cambridge
Department	Zoology
Funding type	Research
Value (£)	126,507
Status	Completed
Type	Research Grant
Start date	16/02/1998
End date	16/02/2001
Duration	36 months

Abstract

Aims: To develop a new family of stochastic models for the dynamics of gastro-intestinal nematode parasites in farmed ruminants, which allow accurately for the generation of parasite aggregation by spatial variations in transmission and heterogeneity in host immune responses. The models will be applied - along with analyses of published and novel epidemiological data - to explore: (a) short and long-term temporal dynamics of parasitism; (b) parasite population genetics (in particular, the persistence of rare parasite genotypes); (c) the population dynamics and genetics of parasite resistance against anthelmintic drugs. Methods: A combination of (a) moment closure equations for the dynamics of parasites within hosts and host immunity; (b) comparing a family of spatial and non-spatial approximations for the parasite transmission process.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Mathematical Modelling Initiative (MMI) [1997]
Funding Scheme	X – not Funded via a specific Funding Scheme

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