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Downstream targets of calcineurin-ZAKI-4 interactions in skeletal muscle: a comparative microarray approach
Reference
LKD20458
Principal Investigator / Supervisor
Professor Kin-Chow Chang
Co-Investigators /
Co-Supervisors
Institution
University of Glasgow
Department
Veterinary Pathology
Funding type
Research
Value (£)
169,672
Status
Completed
Type
Research Grant
Start date
30/04/2004
End date
29/04/2007
Duration
36 months
Abstract
The calcineurin pathway is responsible for a number of phenotypic effects on skeletal muscle, including slow fibre conversion and hypertrophic growth, that are considered favourable to meat quality and quantity. To gain new and reliable insights into the types of target regulatory genes that are transcriptionally activated or, equally important, inhibited by this signalling pathway, this project will exploit a comparative (murine and porcine) microarray approach to investigate the downstream interactions of calcineurin with its endogenous thyroid hormone-inducible inhibitor ZAKI-4 (MCIP2) in muscle cells. This work will further extend to SNP development of candidate target genes with defined effects on muscle quality.
Summary
unavailable
Committee
Closed Committee - Agri-food (AF)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
LINK: Agri-Food Committee (AFL) [1997-2008]
Funding Scheme
X – not Funded via a specific Funding Scheme
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