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Development of novel vaccination strategies for the control of enterohaemorrhagic Escherichia coli in cattle

Reference	LKD19295
Principal Investigator / Supervisor	Professor Mark Stevens
Co-Investigators / Co-Supervisors	Professor Gordon Dougan, Professor Gad Frankel, Dr Pauline M. van Diemen, Dr Timothy Wallis
Institution	The Pirbright Institute
Department	Div of Immunology Compton
Funding type	Research
Value (£)	84,228
Status	Completed
Type	Research Grant
Start date	01/06/2003
End date	31/01/2006
Duration	32 months

Abstract

Enterohaemorrhagic E. coli (EHEC) are emerging zoonotic pathogens and cattle are a major reservoir of human infections. No vaccine for the control of EHEC in cattle is available. Recent work in our laboratory and elsewhere has lead to the identification of two factors that influence intestinal colonisation by EHEC, namely intimin and lymphostatin. We propose to assess the potential of sub-unit vaccines based on these factors for controlling EHEC colonisation in cattle. The efficacy of intimin and lymphostatin polypeptides adjuvated with native E.coli heat- labile toxin or an oil-water mix will be compared following mucosal and parenternal immunisation. This strategy has the potential to reduce carriage of EHEC in farm animal hosts.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	LINK: Agri-Food Committee (AFL) [1997-2008]
Funding Scheme	X – not Funded via a specific Funding Scheme

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