BBSRC Portfolio Analyser
Award details
Regulatory pathways in immunity and infectious disease
Reference
JRI08152
Principal Investigator / Supervisor
Dr Jean Langhorne
Co-Investigators /
Co-Supervisors
Professor Margaret Dallman
,
Professor Gordon Dougan
Institution
Imperial College London
Department
Biological Sciences
Funding type
Research
Value (£)
21,816
Status
Completed
Type
Research Grant
Start date
13/02/1997
End date
13/07/1997
Duration
5 months
Abstract
T-cell responses will be analysed in a variety of different clinically relevant models of allergy, transplantation, mucosal vaccination and infectious diseases. These studies will include characterisation of CD4 and CD8 T-cells in in vivo and in vitro systems involving adoptive transfer, flow cytometry, cell cycle and cytokine measurements. In addition, the fine specificity of the T-cell response to defined antigens of the malaria parasite and the house dust mite will be investigated in order to determine important antigenic epitopes and to enable design of altered peptide ligands for the downregulation of specific immune responses. The signalling and co-stimulation which give rise to modulation of these responses will be determined.
Summary
unavailable
Committee
Closed Committee - Animal Sciences (AS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Joint Equipment Research Initiative 1996 (JE1) [1996]
Funding Scheme
X – not Funded via a specific Funding Scheme
I accept the
terms and conditions of use
(opens in new window)
export PDF file
back to list
new search