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Electrospray LC MSMS mass spectrometer for the characterisation of peptides, proteins and other complex bio- and synthetic molecules

Reference	JRI07360
Principal Investigator / Supervisor	Professor Salvador Moncada
Co-Investigators / Co-Supervisors	Dr David Madge, Professor David Selwood
Institution	University College London
Department	The Cruciform Project
Funding type	Research
Value (£)	82,000
Status	Completed
Type	Research Grant
Start date	01/12/1996
End date	01/06/1997
Duration	6 months

Abstract

Electrospray MSMS will allow the direct sequencing of peptides resulting from protein digests in picomole quantities. This will enable to us to (1) carry out research on the role of aberrant neuronal nitric oxide synthase in the dystrophic diseases (2) to characterise synthetic peptides designed to act as probes of tyrosine kinase mediated cell signalling in cardiovascular and neurodegenerative disease, (3) to accurately determine the molecular weight of DNA-binding peptides, (4) to identify antigenic peptides involved in auto-immune diseases such as rheumatoid arthritis, (5) LC-MS in ES or APCI mode will characterise synthetic molecules designed to act as probes of biological systems such as SKCa channels and CCK serine peptidase (6) the instrument will aid in the characterisation of intermediates in the biosynthetic pathway of erythromycin analogues.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Research Initiative 1996 (JE1) [1996]
Funding Scheme	X – not Funded via a specific Funding Scheme

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