Award details

(A) Influence of Mycobacterium bovis on the T cell stimulatory capacity of bovine antigen-presenting cells

Reference	JRE10834
Principal Investigator / Supervisor	Professor Christopher Howard
Co-Investigators / Co-Supervisors	Professor Ivan Morrison
Institution	The Pirbright Institute
Department	Div of Immunology Compton
Funding type	Research
Value (£)	57,300
Status	Completed
Type	Research Grant
Start date	01/04/1999
End date	01/10/1999
Duration	6 months

Abstract

Over the last 8 years IAH has developed a bovine immunology programme involving the characterisation of cells and molecules of the immune system considered to be essential to provide a fundamental level of understanding of immune processes, focussing on antigen-presenting cells (APC) and their role in regulating the induction of different types of T cell responses. Advances in this area provide the opportunity to initiate a new programme of work on bovine tuberculosis caused by Mycobacterium bovis, which replicates in APC and is controlled by T cell-mediated immune responses. The investigations will determine how infection of APC affects their ability to stimulate T cells, expression of surface molecules and synthesis of cytokines. The role of T cell populations will be investigated in vivo, and in vitro correlates with immunity established. Bovine tuberculosis has been targeted because of its increasing importance as a cattle disease, with attendant risk to human health, and its relevance as a model for human tuberculosis. Since M. bovis is a human pathogen, many of these studies must be carried out in category 3 containment facilities. This proposal seeks funds for equipment to perform flow cytometric analyses and sorting of bovine cells and within the category 3 facilities.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Research Equipment Initiative 1998 (JE3) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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