Award details

(A) The behavioural consequences of inflammation in the central nervous system

Reference	JRE10824
Principal Investigator / Supervisor	Emeritus Professor V Hugh Perry
Co-Investigators / Co-Supervisors	Professor Daniel Anthony
Institution	University of Southampton
Department	Centre for Biological Sciences
Funding type	Research
Value (£)	51,328
Status	Completed
Type	Research Grant
Start date	01/05/1999
End date	01/11/1999
Duration	6 months

Abstract

Neuronal degeneration produces behavioural deficits in diseases such as Alzheimer's disease, Parkinson's disease, prior diseases, and HIV-related dementia. In recent years it has become clear that these diseases have inflammatory components, in addition to the classical neuroinflammatory disease - such as multiple sclerosis and stroke. Given the inflammatory response in these chronic neurodegenerative disease may be susceptible to therapeutic intervention, it is important that we identify the relative contribution that inflammation makes to the pathology. The identification of sickness-related behaviour associated with peripheral inflammation has proved a useful, an non- invasive, tool for assessing disease activity. In a similar manner, we envisage that sickness behaviour associated with inflammation within the brain will also be an extremely useful tool. Indeed, pilot experiments have shown that sickness behaviour is evident before overt pathology is present in the brain in an animal model of chronic neurodegeneration. As a direct consequence, we are now in a position to monitor the effectiveness of therapies earlier in the pathogenesis. Thus, we would like to establish a facility to investigate sickness behaviour in rodent models of neuroinflammation. We will also aim to identify early histopathological markers that may appear in association with such early behavioural changes.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Research Equipment Initiative 1998 (JE3) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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