Award details

(A) X-ray tomography to assess structure of bones and plant roots

Reference	JRE10823
Principal Investigator / Supervisor	Professor T M Skerry
Co-Investigators / Co-Supervisors	Professor Peter Croucher, Professor Alastair Fitter, Professor Ottoline Leyser, Dr Andrew Scutt
Institution	University of York
Department	Biology
Funding type	Research
Value (£)	24,248
Status	Completed
Type	Research Grant
Start date	22/04/1999
End date	22/10/1999
Duration	6 months

Abstract

Increased understanding of the bone remodelling is fundamental to development of new treatments for bone diseases. Our novel finding that communication between bone cells involves the excitatory amino acid glutamate led to projects to determine mechanisms of action of glutamate in bone. In Sheffield, our works focuses on, i) the ability of prostaglandins to influence osteoblast function, ii) mechanisms of bone formation/resorption in multiple myeloma. The equipment will allow rapid accurate longitudinal measurement of bone mass/architectural changes, in response to local/systemic administration of modulators of glutamate and prostaglandin signalling in bone, and assessment of myeloma models. In addition to the accuracy, precision and speed of assessment, this reduces animal usage, since longitudinal studies cut group numbers profoundly. Root architecture is a predominant influence on ability of plants to extract nutrients from soil. While other aspects of plant manipulation receive significant attention, manipulations to increase ability of roots in this respect have been limited because of difficulty in imaging root structure in situ. The equipment will allow 3 dimensional reconstructions of root systems to be made from serial images at regular intervals during growth. This novel application will allow advances in understanding of effect on root phenotype of mutations and genetic manipulations.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Research Equipment Initiative 1998 (JE3) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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