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(A) The role of the intestinal lamina propria in the induction and regulation of mucosal immune responses

Reference	JRE10819
Principal Investigator / Supervisor	Professor Christopher Stokes
Co-Investigators / Co-Supervisors	Professor Michael Bailey, Dr Paul Bland
Institution	University of Bristol
Department	Agricultural Sciences
Funding type	Research
Value (£)	25,000
Status	Completed
Type	Research Grant
Start date	26/03/1999
End date	26/09/1999
Duration	6 months

Abstract

Enteric infection is a major cause of morbidity and mortality in both human and veterinary species. In addition there is a growing appreciation of the social and economic cost of the effects of allergic reactions to ingested antigens. An understanding of the mechanisms of antigen handling at mucosal surfaces is essential to the effective control of these enteric infections and allergic reactions. This project aims to further characterise both the lamina propria T cell and antigen presenting cell (APC) populations. Previously we have shown that intestinal T cells are a highly differentiated population which are susceptible to apoptosis following activation. We have postulated that clonal deletion of these cells may be one mechanism for the maintenance of oral tolerance and we propose to determine whether activation by locally derived MHC class II+ cells results in cell death in an in vitro model using purified CD4+ T cells and sorted allogeneic dendritic cells. The system will be extended by the inclusion of stomal cell types and cytokines to model the effect of the intestinal microenvironment on T cell activation. The effect of local viral and bacterial infection upon these cell types in vivo will be determined.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Research Equipment Initiative 1998 (JE3) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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