Award details

(A) Mass spectrometry instrumentation for rational drug design and discovery of novel peptide protein structures

Reference	JRE10804
Principal Investigator / Supervisor	Professor Kenneth Thomas Douglas
Co-Investigators / Co-Supervisors	Professor Olga Fedorova, Professor John Norton, Dr John Rafferty, Professor Ian Stratford
Institution	The University of Manchester
Department	Manchester Pharmacy School
Funding type	Research
Value (£)	34,000
Status	Completed
Type	Research Grant
Start date	01/01/1999
End date	01/07/1999
Duration	6 months

Abstract

We propose to support the following project areas: 1) the novel self-assembled detectors based on both peptide/protein targets and oligonucleotides/nucleic acids; 2) some newly discovered immunoglobulin-binding peptides; 3) redox- and receptor-activated peptides as macromolecular assemblies for drug delivery and cell penetration; 4) pH-responsive peptides for detection of micro-organisms and vertoxin; 5) study of P-glycoprotein and Aryl Hydrocarbon Receptor (AhR); 6) metabolically stable and immunosilent variants of the DNA repair protein, O6-alkyguanine DNA-transferase for anticancer therapies; 7) the oxidative damage repair protein FPG; 8) development of inhibitors of helix-loop-helix transcription factors, primarily the Hif system of hypoxia and the Id family.

Summary

unavailable

Committee	Closed Committee - Engineering & Biological Systems (EBS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Research Equipment Initiative 1998 (JE3) [1998]
Funding Scheme	X – not Funded via a specific Funding Scheme

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