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BBSRC David Phillips Fellowship A study into the physical properties of the fission yeast myosins
Reference
JF20605
Principal Investigator / Supervisor
Professor Daniel Mulvihill
Co-Investigators /
Co-Supervisors
Institution
University of Kent
Department
Sch of Biosciences
Funding type
Research
Value (£)
394,712
Status
Completed
Type
Fellowships
Start date
01/10/2003
End date
30/09/2008
Duration
60 months
Abstract
To correlate the in vitro biochemical and biophysical properties of these myosins with observations from established in vivo assays to advance our understanding of myosin function in general. The unique aspect of this project is the exploitation of fission yeast genetics allowing precise gene replacement of wild type molecules with those that have been mutated to alter the biophysical/biochemical properties in a defined manner. We will use fast kinetic methods to measure the ATPase and motor activities of microgram quantities of protein on a millisecond time scale in vitro and introduce mutants in which these parameters are altered.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
Microbiology, Structural Biology
Research Priority
X – Research Priority information not available
Research Initiative
Fellowship - David Phillips Fellowship (DF) [1995-2015]
Funding Scheme
X – not Funded via a specific Funding Scheme
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