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BBSRC David Phillips Fellowship Regulation of class II histone deacetylases and MEF2-mediated gene expression by neuronal activity
Reference
JF20603
Principal Investigator / Supervisor
Dr Sangeeta Chawla
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Pharmacology
Funding type
Research
Value (£)
394,844
Status
Completed
Type
Fellowships
Start date
01/07/2003
End date
30/09/2009
Duration
75 months
Abstract
This proposal is to study the mechanisms that regulate the subcellular localisation of class II histone deacetylases HDAC4 and HDAC5, and transcription mediated by MEF-2 proteins in response to electrical activity in hippocampal neurons. Since MEF2 family members are implicated in activity-dependent neuronal survival the research programme will investigate whether MEF2-mediated gene expression is compromised by stimuli such as excitotoxic insults that cause cell death and the mechanisms involved.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
Neuroscience and Behaviour
Research Priority
X – Research Priority information not available
Research Initiative
Fellowship - David Phillips Fellowship (DF) [1995-2015]
Funding Scheme
X – not Funded via a specific Funding Scheme
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