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BBSRC David Phillips Fellowship: Phosphoinositide 3 kinases in lymphocyte activation differentiation and function
Reference
JF19128
Principal Investigator / Supervisor
Professor Klaus Okkenhaug
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Babraham Institute Department
Funding type
Research
Value (£)
371,500
Status
Completed
Type
Fellowships
Start date
01/01/2003
End date
31/12/2007
Duration
60 months
Abstract
To determine the role of PI3Ks in B and T cell signal transduction. To investigate signalling pathways upstream and downstream of specific PI3K isoforms in lymphocytes. To assess differentially roles for specific class IA PI3K isoforms in lymphocytes. To investigate the role for PI3K in Th1 versus Th2 differentiation of T cells. To investigate roles for PI3K in the molecular transforming events leading to B and T cell leukaemia. To generate mice with tissue-specific targeted PI3K mutations. Development of sophisticated gene targeting strategies.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Fellowship - David Phillips Fellowship (DF) [1995-2015]
Funding Scheme
X – not Funded via a specific Funding Scheme
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