Award details

BBSRC David Phillips Fellowship The role of molecular dynamics in extracellular matrix organisation. Investigations of hyaluronan, free and bound to proteins

Reference	JF19103
Principal Investigator / Supervisor	Dr Andrew Almond
Co-Investigators / Co-Supervisors
Institution	University of Oxford
Department	Biochemistry
Funding type	Research
Value (£)	404,720
Status	Completed
Type	Fellowships
Start date	01/10/2002
End date	31/10/2005
Duration	37 months

Abstract

Hyaluronan plays a key role in organising the extracellular matrix, both in its own right by structuring aqueous rich environments (e.g. synovial fluid, vitreous humor) and as an organiser of proteins into fibrillar assemblies. The objectives of the proposal are to understand the dynamics of hyaluronan in a variety of environments within the extracellular matrix. These include: the effects of ions, water molecules, chain length (comparison between short oligosaccharides and large polymers), and how hyaluronan interacts with proteins. The ultimate goal is to understand how these interactions result in the organisation of hyaluronan-rich matrices.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Fellowship - David Phillips Fellowship (DF) [1995-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

Associated awards:

JF19103/2 BBSRC David Phillips Fellowship The role of molecular dynamics in extracellular matrix organisation. Investigations of hyaluronan, free and bound to proteins

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