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Award details
BBSRC David Phillips Fellowship Discovery of antibacterial small molecules with novel modes of action
Reference
JF17001
Principal Investigator / Supervisor
Professor David Spring
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Chemistry
Funding type
Research
Value (£)
394,124
Status
Completed
Type
Fellowships
Start date
01/08/2001
End date
31/03/2006
Duration
56 months
Abstract
The objectives of this proposed research programme are to: (a) Develop methodology to synthesize small molecules on a solid-support using asymmetric synthesis; (b) Synthesize a library of small molecules using diversity-oriented, split-pool synthesis; (c) Identify lead compounds by screening small molecules for their inhibition of bacterial growth with a range of bacteria; and (d) Identify the bacterial targets of the lead compounds and pursue the mechanisms of action of novel targets in molecular detail.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Fellowship - David Phillips Fellowship (DF) [1995-2015]
Funding Scheme
X – not Funded via a specific Funding Scheme
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