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BBSRC David Phillips Fellowship Mechanisms of TNF action in obesity and insulin resistance
Reference
JF16994
Principal Investigator / Supervisor
Professor Jaswinder Sethi
Co-Investigators /
Co-Supervisors
Institution
University of Cambridge
Department
Clinical Biochemistry
Funding type
Research
Value (£)
385,784
Status
Completed
Type
Fellowships
Start date
01/01/2002
End date
31/12/2006
Duration
60 months
Abstract
The specific questions to be addressed in this research programme are; 1). Is TNF alpha utilising the common TRAF2-mediated JNK/p38 activation to modify IRS-1 phosphorylation? 2). What are the intracellular domains of each TNFR that are absolutely required to mediate TNF alpha induced serine phosphorylation of IRS-1? 3). Is JNK and/or p38 activity increased in tissues from obese and type 2 DM subjects and rodents and does this correlate with increased serine phosphorylation of IRS-1? 4). Does TNF alpha-induced modification of IRS phosphorylation impinge on IGFR-TK in a fashion that is analogous to IR signalling?
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Fellowship - David Phillips Fellowship (DF) [1995-2015]
Funding Scheme
X – not Funded via a specific Funding Scheme
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