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Activation of Drosophila TRP channels; role of lipid messengers in regulating calcium influx
Reference
JF14820
Principal Investigator / Supervisor
Professor Raghu Padinjat
Co-Investigators /
Co-Supervisors
Institution
Babraham Institute
Department
Molecular Signalling
Funding type
Research
Value (£)
393,313
Status
Completed
Type
Fellowships
Start date
15/10/2000
End date
14/10/2005
Duration
60 months
Abstract
In order to understand the functions of DAG in regulating Ca2+ influx, this project will use the Drosophila photoreceptor as a model system to achieve the following goals: 1) use a highly selective forward genetic approach to isolate mutants in which DAG dependent signalling in photoreceptors is affected; 2) use reverse genetic approaches to identify gene encoding enzymes that function in DAG signalling and generate mutants in these; and 3) analyse phototransduction in these mutants to establish the physiological significance of DAG and its metabolites in activating the Drosophila light sensitive channels TRP and TRPL.
Summary
unavailable
Committee
Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Fellowship - David Phillips Fellowship (DF) [1995-2015]
Funding Scheme
X – not Funded via a specific Funding Scheme
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