Award details

BBSRC David Phillips Research Fellowship Structural and engineering studies of beta-propeller proteins : using modelling and selection to evolve novel folds

Reference	JF11145
Principal Investigator / Supervisor	Dr Max Paoli
Co-Investigators / Co-Supervisors
Institution	University of Cambridge
Department	Biochemistry
Funding type	Research
Value (£)	231,096
Status	Completed
Type	Fellowships
Start date	20/07/1998
End date	20/07/2003
Duration	60 months

Abstract

The objectives of the proposed research programme are to: a) Achieve an understanding of the structural architecture of proteins with a beta-propeller fold; b) Explore the structural role of factors contributing to the architecture of the beta- propeller fold; c) Determine and analyse the structure of a naturally occurring new beta-propeller fold; d) Design and engineer a new version of the known fold, using combined modelling and genetic selection approaches. The targets to be met include: a) A comparative analysis of beta-propeller structures, seeking rules and leading to a written review (1/2 year 1); b) Design and engineer a 5-bladed beta-propeller (year 1 and 2), and study its structure (years 3, 4 and 5); c) Purify/crystallise (year 2) the protein coronin, a putative 5-bladed propeller, determine and analyse its structure (year 3, 4 and 5); d) Crystallisation/structure determination of one domain of WAP65 (years 1 and 2); work on the whole molecule (years 3, 4 and 5).

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Fellowship - David Phillips Fellowship (DF) [1995-2015]
Funding Scheme	X – not Funded via a specific Funding Scheme

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