BBSRC Portfolio Analyser
Award details
A- Structural determination and refinement of protein structures of commercial importance in biotransformation reactions
Reference
JEI09406
Principal Investigator / Supervisor
Professor Jennifer Littlechild
Co-Investigators /
Co-Supervisors
Institution
University of Exeter
Department
Biosciences
Funding type
Research
Value (£)
41,000
Status
Completed
Type
Research Grant
Start date
27/03/1998
End date
27/09/1998
Duration
6 months
Abstract
This proposal is to support computing for the structural biological chemistry group at Exeter University headed by Dr J. Littlechild. The computing power available to us at present funded by BBSRC and Wellcome Trust is not of sufficient size to allow us to progress with refinement of high resolution structures of enzymes important in biotransformation reactions or to carry out molecular modelling and dynamics on enzyme/substrate/inhibitor complexes. The Origin 200 computer system in this bid will allow us to work efficiently 'in house' and allow development of our group in this important area of research. Funding for our research comes from project grants supported by both ROPA awards and as part of the Chemical and Pharmaceutical Directorate of the BBSRC and charities such as the Wellcome Trust. We have LINK programme grants with Chiroscience and CASE studentships with SmithKline Beecham, Chiroscience and British Biotechnology. Structural information at high or atomic resolution of enzymes used in chemical synthesis is of vital importance to the pharmaceutical industry for the synthesis of homochiral drugs or synthons. An understanding of the enzyme mechanism which is of both generic and industrial interest will allow redesign of these enzymes to optimise their use in biocatalysis. Support for this equipment bid will help us to achieve these ends.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Joint Research Equipment Initiative 1997 (JE2) [1997]
Funding Scheme
X – not Funded via a specific Funding Scheme
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