Award details

Investigation of receptor-ligand interactions using the BIAcore 2000

Reference	JEI09404
Principal Investigator / Supervisor	Professor Nigel Dimmock
Co-Investigators / Co-Supervisors	Professor H Dalton, Professor Edward Hillhouse
Institution	University of Warwick
Department	Biological Sciences
Funding type	Research
Value (£)	76,896
Status	Completed
Type	Research Grant
Start date	04/03/1998
End date	04/09/1998
Duration	6 months

Abstract

The BIAcore 2000 is a versatile and reliable instrument that analyses receptor-ligand interactions in real time, and provides both affinity and kinetic data. One of the reactants is immobilised on the sensor and provides the base line, while it is the association and/or dissociation of the second, free flowing component that is quantitated. The immobilised component can be as large as a whole virus particle, and interaction with a second component as small as 180 Mr can be detected. This application outlines three projects from different research groups within the Department of Biological Sciences, in the fields of the mechanism of action of novel peptide-sized anti-viral miniantibodies, the proteolytic activation of plasmin, and the interaction of corticotrophin-releasing hormone and its receptor. Many more projects will be enabled by the installation of the BIAcore instrument in the Department. The BIAcore 2000 is the top of the range machine that is readily justified by its high sensitivity and great throughout capacity. It will be of major benefit to the 300 plus researchers in our grade 5-rated Department.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Research Equipment Initiative 1997 (JE2) [1997]
Funding Scheme	X – not Funded via a specific Funding Scheme

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