Award details

A high performance computer for protein crystallography

Reference	JEI09383
Principal Investigator / Supervisor	Professor Dame Louise Johnson
Co-Investigators / Co-Supervisors	Dr Richard Bryan, Professor David Stuart
Institution	University of Oxford
Department	Laboratory of Molecular Biophysics
Funding type	Research
Value (£)	50,000
Status	Completed
Type	Research Grant
Start date	01/02/1998
End date	01/08/1998
Duration	6 months

Abstract

The application seeks support for a high performance computer for research in protein crystallography within the collaborative environments of the Oxford Centre for Molecular Sciences and the Laboratory of Molecular Biophysics, Oxford. Current structural work addresses problems in: macromolecular assemblies, including viruses and cell cycle regulatory complexes; in enzyme mechanism and control, including penicillin biosynthesis, protein phosphatase activity, time resolved studies and protein carbohydrate interactions; in cell-cell recognition processes of antigen presentation and cell adhesion; in the structural basis of drug interactions and amyloidogenesis; and in high resolution structural refinement of large proteins. We seek to replace our current DEC Alpha 2100 with a faster computer to meet our increasing requirements for computer intensive aspects of crystallographic computing. Our needs are best met by a multi processor server with large main memory, so that all resources, especially memory, may be concentrated in a single job when necessary, or shared between multiple jobs. We have bench marked appropriate computers and have selected a four processor DEC Alpha 4100 as the best offer. The computer manufacturer has agreed to sponsor the purchase with a 50 percent donation additional to the 30 percent educational discount in recognition of the work carried out at Oxford University and the benefits the collaboration will bring to both parties.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Research Equipment Initiative 1997 (JE2) [1997]
Funding Scheme	X – not Funded via a specific Funding Scheme

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