Award details

High throughput purification and analysis of proteins of therapeutic interest

Reference	JEI09357
Principal Investigator / Supervisor	Dr Katherine Brown
Co-Investigators / Co-Supervisors	Professor Gordon Dougan, Professor Neil Fairweather
Institution	Imperial College London
Department	Biological Sciences
Funding type	Research
Value (£)	21,484
Status	Completed
Type	Research Grant
Start date	19/01/1998
End date	19/07/1998
Duration	6 months

Abstract

The ever-increasing number of drug-resistant and multi-drug resistant microorganisms demands new research in areas of vaccinology and anti-microbials in order to develop safe, effective therapeutic agents. The availability of genomic data for a number of pathogenic organisms, improved expression systems for recombinant genes, and other emerging technologies including proteomics is improving the ease with which new protein targets are identified. We are seeking a high throughput facility for the rapid development of purification protocols and preparative scale- up of proteins of therapeutic interest. This will accelerate our functional and structural studies which depend upon the availability of substantial quantities of purified proteins. In the area of therapeutic development targeted by this proposal, these studies will include such diverse disciplines as enzymology, vaccinology, cell biology, immunology and X-ray crystallography. Specifically, a protein purification workstation is requested which will be utilised by a consortium of users who share a common interest in the characterisation of novel proteins from pathogenic bacteria and fungi which may contribute either to the virulence of the microbe, or which are candidate targets for the development of anti-microbial drugs.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Research Equipment Initiative 1997 (JE2) [1997]
Funding Scheme	X – not Funded via a specific Funding Scheme

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