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A fluorescence lifetime system for the study of protein structure and function

Reference	JE616484
Principal Investigator / Supervisor	Professor Anthony Lee
Co-Investigators / Co-Supervisors	Professor Michael Gore, Dr D Wilton
Institution	University of Southampton
Department	Centre for Biological Sciences
Funding type	Research
Value (£)	40,092
Status	Completed
Type	Research Grant
Start date	01/03/2002
End date	01/03/2003
Duration	12 months

Abstract

Fluorescence techniques are being used to study a number of proteins and their interactions with other molecules in attempts to correlate structure and function relationships. Examples include the characterisation of the interaction between bacterial immunoglobulin (Ig)-binding proteins and Igs, Fab and ScFv; the use of fluorescence energy transfer between Ca-ATPase and phospholamban to fluorescence quenching studies of simple alpha-helical peptides in lipid bilayers; the topology of porins in lipid bilayers; structural studies of C2 domains of protein kinases and binding of sPLA2 to bilayers; studies of the phosphorylated zeta chain from the T-cell receptor to SH2 domains on protein kinases; studies of the stability of multistranded DNA; studies of the conformation of small peptides at model interfaces.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2001 (JE6) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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