Award details

In vivo analyses of canine limb mechanics in normal and lame gaits

Reference	JE616473
Principal Investigator / Supervisor	Dr Catherine Fuller
Co-Investigators / Co-Supervisors	Dr Jeremy Burn, Dr G Colborne, Dr John Innes, Dr Martin Owen
Institution	University of Bristol
Department	Anatomy
Funding type	Research
Value (£)	24,096
Status	Completed
Type	Research Grant
Start date	01/01/2002
End date	01/01/2003
Duration	12 months

Abstract

Animal models will be used to study biomechanics in normal and lame gaits. An initial study will use kinematic and kinetic gait analysis to investigate in vivo mechanics in canine cruciate ligament (CCL) disease. Knowledge of the mechanics of the normal and diseased canine stifle joint is pivotal to the understanding of the pathogenesis of this disease. Canine cruciate disease is common in breeds such as the Labrador Retriever, but rare in others such as the Greyhound. Work at Bristol has documented differences in CCL collagen metabolism and concentration of matrix metalloproteinases as normal ligaments from these breeds. Biomechanical differences in stifle joint function may be responsible for alterations in CCL loading patterns causing different biochemical responses in ligaments. Work done across the stifle during normal movement has not been investigated, and the alterations that occur in these forces following CCL rupture and subsequent surgical repair have not been studied. The initial study will investigate joint power and work of the normal stifle in two breeds of dog (Labrador Retriever and Greyhound) and the abnormalities these parameters in Labradors with CCL rupture, which will help to elucidate the contribution of biomechanics to ligament degeneration.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2001 (JE6) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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