Award details

Use of dual energy X-ray absorptiometry to assess bone density in transgenic mouse

Reference	JE616451
Principal Investigator / Supervisor	Professor Timothy Arnett
Co-Investigators / Co-Supervisors	Professor Alan Boyde, Professor Geoffrey Burnstock, Dr Martin Rosendaal
Institution	University College London
Department	Structural Molecular Biology
Funding type	Research
Value (£)	25,500
Status	Completed
Type	Research Grant
Start date	29/01/2002
End date	29/01/2003
Duration	12 months

Abstract

The laboratories interested in skeletal research at UCL form the largest such grouping in the UK, with longstanding collaborations. We need an efficient method for detecting changes in skeletal phenotype in the many strains of transgenic mice that we now study. The method of choice is the GE/Lunar PIXImus dual energy X-ray absorptiometer, a high throughput instrument specifically designed for measuring bone mineral density in small, sedated rodents. The instrument would be used monitoring bone density in mice deficient in: P2 receptor or ecto- nucleotide pyrophosphatase; connexin-43-deficient mice; tartrate-resistant and lysosomal acid phosphatases; cathepsin K; Cbfa 1; the glutamate transporter GLAST; biglycan and decorin; collagen type X; interleukin-4 and interferon-gamma. Additional studies with PIXImus will include: bacterial bone pathology and the osteolytic role of molecular chaperones; osteopetrosis; the osteolytic action of acidosis and hypoxia; antiresorptive drug development. In view of the concentration of the molecular biology/transgenic mouse research at UCL, there are likely to be many unforeseen future applications. The proposal represents excellent value for money and will provide a new focus of collaboration for our laboratories.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2001 (JE6) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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