Award details

Computational structural biology and structural bioinformatics

Reference	JE616430
Principal Investigator / Supervisor	Professor Sir Tom Blundell
Co-Investigators / Co-Supervisors
Institution	University of Cambridge
Department	Biochemistry
Funding type	Research
Value (£)	198,964
Status	Completed
Type	Research Grant
Start date	18/12/2002
End date	18/12/2003
Duration	12 months

Abstract

Structural biology in the coming decade will be focusing on two complementary objectives. The determination of the structures of the individual gene products defined by the newly sequenced genomes. These should give clues about the function when this is not evident from sequence alone, as function depends on 3D structure and structure is more conserved in evolution than sequence. The definition of the structures of the multiprotein complexes that mediate the functions of the great majority of cell regulatory systems, including those involved in receptor activation, signal transduction, transcription, translation and so on. The objective will be to bridge between the structures of individual macromolecular components and the structures of the cellular organelles, often defining transient systems. Our proposal involves three elements of structural biology and structural bioinformatics: comparative genomics and fold recognition; ab initio prediction of protein structure; and experimental structure determination. All require intensive computing power, for which the IBM Intel-based multi-processor computer system is ideally suited.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2001 (JE6) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search