Award details

Studies on anti-carcinogenic compounds in cruciferous vegetables and other plants

Reference	JE616398
Principal Investigator / Supervisor	Professor Richard Mithen
Co-Investigators / Co-Supervisors	Professor Ian Macdonald, Dr P Shaw
Institution	University of Nottingham
Department	Sch of Biosciences
Funding type	Research
Value (£)	96,960
Status	Completed
Type	Research Grant
Start date	18/04/2002
End date	18/04/2003
Duration	12 months

Abstract

The University of Nottingham has initiated a major interdisciplinary research programme on diet and health, involving collaboration between the Schools of Bioscience, Biomedical Science and Pharmaceutical Sciences. This award will fund a LC-MS system for the analysis of potential anticarcinogenic compounds in cruciferous vegetables. Epidemiological and physiological experiments have provided substantive evidence that the consumption of crucifers can reduce the risk of cancer, particularly of the gastro-intestinal tract and lung. A range of metabolites in crucifers have been associated with anticarcinogenic activity. Foremost amongst these are isothiocyanates (ITCs) derived from glucosinolates. ITCs have been shown to be potent inducers of phase2 detoxification enzymes and can induce apoptosis of potentially carcinogenic cells. The programme involves the analysis and manipulation of the levels of glucosinolates and ITCs by both conventional and transgenic means, the analysis of human ITC metabolites and the analysis of other crucifer metabolites. Previous experience has shown that the requested LC-MS provides an exceptionally good resource to facilitate these studies. The programme will be extended to other crops and model plant species. The equipment will make a major contribution to the research and training capabilities of the Crop Science section of the School of Biosciences. The equipment will be partially used within a programme sponsored by Seminis, but it will be used for a variety of other programmes sponsored by BBSRC and other sources.

Summary

unavailable

Committee	Closed Committee - Agri-food (AF)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2001 (JE6) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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