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Proteomic approach to functional genomics using tandem mass spectroscopy and isotope coded affinity tags

Reference	JE616392
Principal Investigator / Supervisor	Professor Antony Slabas
Co-Investigators / Co-Supervisors	Professor Robert Edwards, Professor P Hussey, Professor Christopher Hutchison, Professor Keith Lindsey, Professor Stefan Przyborski, Professor Roy Quinlan
Institution	Durham University
Department	Biological and Biomedical Sciences
Funding type	Research
Value (£)	188,508
Status	Completed
Type	Research Grant
Start date	14/03/2002
End date	14/03/2003
Duration	12 months

Abstract

We aim to use tandem mass spectroscopy plus isotope coded affinity tags to study a range of different biological problems. Key to this process is sample handling and provision of amino acid sequence data. The areas to be investigated are: 1) Arabidopsis and corn cell wall proteins, 2) The Endoplasmic Reticulum of Ricinus and enzymes of complex lipid biosynthesis, 3) Responses of corn and Arabidopsis suspension cultures to biotic and abiotic stress. 4) Cyanobacterial membrane proteins and temperature adaptation, 5) Macromolecular associations, 6) Laminopathy, 7) Stem cell differentiation and cell signalling pathways, 8) The role of chaperone-cytoskeleton inclusions in cell pathology, 9) Functional genomics photoaffinity labelling, 10) Active site characterisation of enzymes and confirmation of reaction mechanism, and 11) Identification of novel biocatalysts from plants.

Summary

unavailable

Committee	Closed Committee - Plant & Microbial Sciences (PMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2001 (JE6) [2001]
Funding Scheme	X – not Funded via a specific Funding Scheme

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