Award details

(A) Targeted electrophysiological studies in brain slices

Reference	JE514656
Principal Investigator / Supervisor	Professor Gareth Leng
Co-Investigators / Co-Supervisors	Professor Mayank Dutia
Institution	University of Edinburgh
Department	Biomedical Sciences
Funding type	Research
Value (£)	22,680
Status	Completed
Type	Research Grant
Start date	01/04/2001
End date	01/10/2001
Duration	6 months

Abstract

Two major areas of interest in the Neural Control Systems Group are (a) the regulation of feeding behaviour by hypothalamic neurones (supported by Merck & Co), and (b) the cellular mechanisms of plasticity in vestibular nucleus neurones during behavioural recovery after vestibular lesions (supported by the Wellcome Trust). In both these areas significant advances have been made in the past few years, but the detailed study of these systems in slices in vitro impeded by the fact that in both cases the neurones of interest are found interspersed with other neuronal types, within the arcuate and medial vestibular nuclei respectively. Here we propose to identify and make targeted electrophysiological recordings from the neurones of interest, by retrogradely labelling them with fluorescent beads injected into their target areas some days prior to slice preparation. Targeted studies of functionally identified neurones in this way will allow us to directly address a number of current questions related to the control of feeding and neural plasticity, as well as enable further new studies in these areas.

Summary

unavailable

Committee	Closed Committee - Animal Sciences (AS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2000 (JE5) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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