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Award details
(A) Probing molecular function with synthetic peptides
Reference
JE514443
Principal Investigator / Supervisor
Professor Rudolf Allemann
Co-Investigators /
Co-Supervisors
Professor Edwin Constable
,
Professor Kenneth Harris
,
Dr Oliver Smart
,
Dr John Snaith
,
Dr Maryjane Tremayne
,
Dr H Tye
Institution
University of Birmingham
Department
School of Chemistry
Funding type
Research
Value (£)
32,372
Status
Completed
Type
Research Grant
Start date
13/06/2001
End date
13/06/2002
Duration
12 months
Abstract
The projects described in this proposal seek to use synthetic peptides to study the fundamental processes underlying disease, gene transcription, enzyme catalysis, protein folding and structure. Birmingham is in an excellent position for conducting interdisciplinary research of this nature, with a superb infrastructure including high field NMR, mass spectrometry, X-ray instrumentation and a newly acquired CD spectrometer. Collaborative links are very strong under a broad umbrella of biomolecular sciences. All of the projects described require the routine availability of a wide variety of peptides, the majority incorporating highly unusual unnatural amino acids. The synthesis of such sequences will require the adaptation and optimisation of standard coupling protocols, with on-line monitoring of coupling efficiency to aid method development. Commercial synthesis of such peptides, particularly involving extensive method development, would be overly expensive. For the maintenance of our internationally competitive position within the areas described the purchase of a peptide synthesiser is essential.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Joint Equipment Initiative 2000 (JE5) [2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
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