Award details

(A) Centrifugation facility for the design discovery and characterisation of novel drugs and materials

Reference	JE514397
Principal Investigator / Supervisor	Professor Brian Houston
Co-Investigators / Co-Supervisors	Dr Jill Barber, Professor Peter Budd, Professor Kenneth Thomas Douglas, Professor Peter Gilbert, Professor Ian Stratford
Institution	The University of Manchester
Department	Manchester Pharmacy School
Funding type	Research
Value (£)	56,316
Status	Completed
Type	Research Grant
Start date	01/02/2001
End date	01/08/2001
Duration	6 months

Abstract

A series of projects will be undertaken which encompass a wide range of biological areas of research. However as all rely heavily on the use of subcellular fractions in order to purify, at least to some degree, the macromolecules under investigation, the need for access to a reliable medium speed ultracentrifugation facility is essential. Specifically the projects are: 1) extrapolation of in vitro hepatic drug metabolism data to predict in vivo drug disposition; 2) the control of microbial biofilms; 3) antibiotic inhibitors of bacterial protein synthesis; 4) the preparation and characterisation of perdeuteriated proteins; 5) novel target- assembled latent detectors; 6) O6-Alkylguanine DNA-alkyltransferase; 7) repair of oxidative damage to DNA by the FPG protein; 8) new materials from renewable resources; 9) hypoxia in tumours and human disease; and 10) design and development of inhibitors of hypoxia inducible factor (Hif) transcription factor dimerisation as potential anti-cancer drugs.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2000 (JE5) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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