Award details

(I) Measuring heterogeneity in cell populations using array imaging infrared microscopy (AIIM)

Reference	JE514384
Principal Investigator / Supervisor	Dr Maureen McCann
Co-Investigators / Co-Supervisors	Dr Reg Wilson
Institution	John Innes Centre
Department	Cell and Develop Biology
Funding type	Research
Value (£)	50,000
Status	Completed
Type	Research Grant
Start date	10/12/2001
End date	10/06/2002
Duration	6 months

Abstract

The aim of this proposal is to provide the John Innes Centre (JIC) with a state-of-the-art Fourier transform infrared microscope with focal plane array detector for the detection and quantification of the molecular chemistry of microscopic samples. The capability of performing spatially-resolved chemical analyses of microscopic regions of samples in situ will underpin 11 multi-disciplinary projects at JIC and at the neighbouring Institute of Food Research (IFR) and Sainsbury Laboratory. The choice of an array imaging infrared microscope (AIIM) will relieve the pressure on existing equipment based at IFR but potentiate new applications of the technology, including infrared-based mutant screens for microbes, the applications of infrared microscopy to living cells, and the capability of localising chemical changes in specimens occurring over a time-scale of minutes, for example, responses of plant tissues to pathogen attack or to applied mechanical stresses. Both JIC and IFR are contributing to costs from funds raised from industrial overheads, with direct industrial support from Zeneca and SatCo Ltd, such that 50% of cost is sought from JREI. The equipment will be made accessible to all laboratories on the Norwich Research Park, and to visiting UK academic and industrial users, to promote inter-disciplinary research between the chemical and biological sciences.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2000 (JE5) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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