Award details

(A) Confocal microscopy imaging unit: studies of cell signalling gene manipulation and anti-oxidant defence in health and disease

Reference	JE514332
Principal Investigator / Supervisor	Dr Timothy Cowen
Co-Investigators / Co-Supervisors	Dr Mark Cooper, Professor Geoffrey Goldspink, Professor James Owen, Dr Christopher Thrasivoulou
Institution	University College London
Department	Department of Anatomy and Developmental
Funding type	Research
Value (£)	103,200
Status	Completed
Type	Research Grant
Start date	31/05/2001
End date	31/08/2001
Duration	3 months

Abstract

A new confocal microscope system is proposed, linked to an existing image analysis facility and sited in a laboratory refurbished for this purpose. The whole will comprise a confocal, light and fluorescence microscope imaging unit. The new system will replace an outmoded confocal microscope. Improved resolution and sensitivity, reduced photobleaching damage of live cells, lasers allowing a wider range of fluorophors and sophisticated three-dimensional imaging software offer important advantages to the research status of the institution as well as to the individual projects. Projects are proposed which will utilise the full potential of the new equipment. Receptors and signalling pathways will be studied in a clinically directed project analysing the role of ApoE receptors an nitric oxide signalling in the cardiovascular system. A transgenic approach will be used to study the role of a novel family of membrane proteins in neuronal plasticity. Gene manipulations of a novel growth factor will be used to study mechanisms underlying growth and damage in muscle cells. Finally, a confocal assay of free radical generation, developed recently by the award holders, will be used to assess antioxidant defence and vulnerability in model systems of disease and ageing in the nervous system.

Summary

unavailable

Committee	Not funded via Committee
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2000 (JE5) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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