Award details

(A) High resolution magnetic resonance imaging; a tool for biology

Reference	JE514324
Principal Investigator / Supervisor	Professor Kevin Brindle
Co-Investigators / Co-Supervisors	Dr Catherine Boulter, Professor Charles ffrench-Constant, Professor Robin Franklin, Professor Stephen Oliver, Professor David Parker, Dr Richard Sandford
Institution	University of Cambridge
Department	Biochemistry
Funding type	Research
Value (£)	150,000
Status	Completed
Type	Research Grant
Start date	26/03/2001
End date	26/09/2001
Duration	6 months

Abstract

In the post-genomic area we need new tools to analyse the phenotypic changes that result from gene modification and thus to assign functions to specific genes. High resolution magnetic resonance imaging (MRI) and spectroscopy provide us with such tools. MRI will be used here to examine the morphological changes that result from gene mutation in transgenic mice and high resolution spectroscopy will be used to screen for metabolic changes in yeast gene deletion mutants. In addition to determining tissue morphology MRI can also, with the use of appropriate probe molecules, give high resolution information on underlying tissue biochemistry and physiology. A major theme of this project will be to develop approaches for measuring tissue pH, apoptosis and cell migration using novel contrast agents. The project will expand existing MRI technology, creating new applications and extending it into new areas of biology, where currently there is little appreciation of its potential.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2000 (JE5) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

I accept the terms and conditions of use (opens in new window)

export PDF file

back to list new search