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Award details
(A) Advanced protein and nucleic acid purification facility for structural proteomics
Reference
JE514297
Principal Investigator / Supervisor
Dr John Rafferty
Co-Investigators /
Co-Supervisors
Institution
University of Sheffield
Department
Molecular Biology and Biotechnology
Funding type
Research
Value (£)
52,972
Status
Completed
Type
Research Grant
Start date
01/10/2001
End date
01/04/2002
Duration
6 months
Abstract
Equipment is requested that will be vital in establishing a state of the art structural proteomics laboratory capable of handling large numbers of samples for the production of milligramme quantities of purified proteins and DNA or RNA oligonucleotides for use in structural biology investigations. The laboratory will support research within the Krebs Institute at the University of Sheffield into the structure and function of biological macromolecules, including current work on the rational design of novel antibiotics, the folding of proteins involved in amyloidogenic diseases and therapeutic targets of interest to our industrial collaborator British Biotech. The objective is to provide critical structural insights into macromolecular assembly and function of targets arising out of conventional biomedical analysis and genomic initiatives such as those underway into S. pombe, zebrafish and humans and to advance current proteomics research in the Krebs Institute based on functional data that has been developed from bacterial genome sequencing initiatives such as that of B. subtilis. The requested equipment will enable the Krebs Institute to meet the challenges posed by genomic science and to play an important role in the proteomics revolution which seeks to utilize the sequence data.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Joint Equipment Initiative 2000 (JE5) [2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
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