Award details

(A) Transcriptome analysis facility for the Krebs Institute

Reference	JE514294
Principal Investigator / Supervisor	Professor Geoffrey Turner
Co-Investigators / Co-Supervisors	Dr Penny Rashbass
Institution	University of Sheffield
Department	Molecular Biology and Biotechnology
Funding type	Research
Value (£)	23,980
Status	Completed
Type	Research Grant
Start date	01/02/2001
End date	01/02/2002
Duration	12 months

Abstract

A number of different eukaryotic experimental systems, from microbes to mammals, are studied in current research projects within the Krebs Institute. Several of these projects are at a stage where they need to take advantage of the recently developed techniques for transcriptional profiling using microarrays. Equipment is requested for imaging and analysis of microarrays following hybridisation with a variety of different probes. The microarrays will be produced externally. Arrangements for provision of these have already been made for 2 initial projects which examine gene expression profiles in order to (a) relate morphological change in the filamentous fungus Aspergillus nidulans which will identify signalling pathways involved in polar growth of fungal hyphae and (b) compare normal and mutant mammalian eye development so that genes can start being assigned into groups which share common regulatory properties. As further microarrays become obtainable from user community projects or commercial sources, other groups within the Krebs Institute wish to take advantage of this methodology. These include projects on (i) axon development in Zebra fish (ii) role of the Whn transcription factor in mammalian hair follicle development, and (iii) differentiation of mammalian gut enterocytes in response to dietary stimulation.

Summary

unavailable

Committee	Closed Committee - Genes & Developmental Biology (GDB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2000 (JE5) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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