Award details

(A) A high precision automated spot cutter for expansion of the proteomics facility at Aberystwyth

Reference	JE514293
Principal Investigator / Supervisor	Professor Peter Brophy
Co-Investigators / Co-Supervisors	Professor John Barrett, Professor John Draper, Professor Royston Goodacre, Professor William Haresign, Professor Douglas Kell, Professor Steven Kelly, Dr Ian Scott, Dr Basil Wolf
Institution	Aberystwyth University
Department	Inst of Biological, Environ & Rural Sci
Funding type	Research
Value (£)	60,043
Status	Completed
Type	Research Grant
Start date	01/01/2001
End date	01/07/2001
Duration	6 months

Abstract

This proposal requests new infrastructure support to purchase a Biorad Proteome Works Spot-Cutter system for expansion of functional genomic research in the multi-institution based Aberystwyth Biocentre (ABC). Research scientists within ABC are pioneering new developments in proteome technology and also incorporating proteomics to address the Research Council funded problems and land based bio-sciences. The system requested interfaces with current BBSRC/HEFCW funded equipment, including a Micromass MALDI-TOF-MS system. Two proteome equipment manufacturers (BioRad and Micromass) have co- operated to develop an automated protein-spot identification system that removes a process bottleneck between upstream and downstream proteomics, and provides both greater reproducibility and higher throughput. The project between ABC and BioRad is in the area of spot detection algorithms for 2-D gels, specifically in the optimisation of glycoprotein analysis. Thus, as a result of our background in protein biochemistry we have negotiated a significant collaboration. The application is driven by specific research council proteome projects in veterinary parasitology and medical microbiology. The proteome suite at Aberystwyth also underpins a number of currently funded BBSRC functional genomic projects and other new pump priming research themes.

Summary

unavailable

Committee	Closed Committee - Biochemistry & Cell Biology (BCB)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2000 (JE5) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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