Award details

(A) Structural studies of protein-protein and protein-ligand interactions

Reference	JE514284
Principal Investigator / Supervisor	Dr Eva Hyde
Co-Investigators / Co-Supervisors	Professor Rudolf Allemann, Dr Klaus Futterer, Professor Baz Jackson, Professor R Jefferis, Dr Barry Levine, Dr Peter Searle, Dr Oliver Smart, Professor Jeremy Turnbull, Dr Scott Andrew White, Professor Lawrence Young
Institution	University of Birmingham
Department	Sch of Biosciences
Funding type	Research
Value (£)	91,692
Status	Completed
Type	Research Grant
Start date	05/03/2001
End date	15/09/2001
Duration	6 months

Abstract

Structural studies of protein-protein and protein-ligand interactions underpin the detailed understanding of biological processes. This proposal seeks to upgrade structural biology equipment that supports research programmes at the interface between Life and Physical sciences at the University of Birmingham. The equipment is used by a number of groups that collaborate widely across the Schools of Bioscience, Medicine and Chemistry. The studies range from protein-small ligand interactions of transhydrogenase, nitroreductase and pyrophosphatase; through protein-DNA interactions of basic helix-zipper proteins and NifA; protein- oligosaccharide interactions of FGF and IgG molecules and protein-protein interactions involving enteropeptidase, EBV latent membrane protein 1, phospholamban and caldesmon. This structural work underpins multidisciplinary studies aimed towards understanding the interactions that are critical to biological function. It is also relevant to the development of novel therapies and technologies with potential medical or commercial applications. The equipment requested will greatly enhance the sensitivity of existing X-ray and NMR facilities. This will increase the capacity and throughput of projects while improving the precision and accuracy of the structural data acquired. The equipment will also improve molecular graphics facilities for structural studies and will allow us to develop structural studies in the emerging area of protein-saccharide interactions.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2000 (JE5) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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