Award details

(A) Equipment for protein purification for biosynthetic and enzyme mechanism studies

Reference	JE514269
Principal Investigator / Supervisor	Professor Thomas Simpson
Co-Investigators / Co-Supervisors	Professor Russell Cox, Dr John Crosby
Institution	University of Bristol
Department	Chemistry
Funding type	Research
Value (£)	77,116
Status	Completed
Type	Research Grant
Start date	29/03/2001
End date	29/09/2001
Duration	6 months

Abstract

Funding for state-of-the-art protein purification equipment is requested to underpin the work of several research groups in Bristol. This includes structural and mechanistic studies on polyketide synthases from fungal and bacterial sources and the enzymes involved in post-polyketide modifications, with a view to producing new bioactive molecules; studies on the enzymes of amino acid and other primary metabolic pathways aimed at the design of mechanism-based inhibitors; structural and mechanistic studies on individually expressed domains of fatty acid synthases and the novel enzymes involved in fatty acid elongation processes; isolation and characterisation of chlorinating and other enzymes from marine metabolic pathways to study their potential for biotransformation. These studies involve extensive collaborations within Bristol and with several groups in the UK and elsewhere.

Summary

unavailable

Committee	Closed Committee - Biomolecular Sciences (BMS)
Research Topics	X – not assigned to a current Research Topic
Research Priority	X – Research Priority information not available
Research Initiative	Joint Equipment Initiative 2000 (JE5) [2000]
Funding Scheme	X – not Funded via a specific Funding Scheme

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