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(A) Confocal MaxFlux optics for protein crystallography
Reference
JE514265
Principal Investigator / Supervisor
Professor Robert Conlan
Co-Investigators /
Co-Supervisors
Institution
University of Warwick
Department
Biological Sciences
Funding type
Research
Value (£)
25,248
Status
Completed
Type
Research Grant
Start date
30/09/2001
End date
30/03/2002
Duration
6 months
Abstract
The application seeks support for a high performance X-ray focusing mirrors system combined with an upgrade of the rotating anode for research in protein crystallography within the multidisciplinary environment of the Department of Biological Sciences, University of Warwick. Our current structural work addresses problems in: enzyme mechanism and control, including oligopeptidases, AAA proteases, denitrifying enzymes, peroxidases and other bacterial redox enzymes, time resolved studies; ribosome inactivating proteins; penicillin-binding proteins; virus proteins; signalling proteins; and corticotrophin and oxytocin receptors. We seek to replace our platinum coated focusing mirrors and the rotating anode on our Enraf Nonius generator to meet our increasing requirements for fast and reliable X-ray data collection. Our needs are best met by a Confocal MaxFlux grated mirrors optics system combined with a 6 kW High-Flux anode. This system offers an order of magnitude increase in intensity with high monochromaticity and easy and simple alignment.
Summary
unavailable
Committee
Closed Committee - Biomolecular Sciences (BMS)
Research Topics
X – not assigned to a current Research Topic
Research Priority
X – Research Priority information not available
Research Initiative
Joint Equipment Initiative 2000 (JE5) [2000]
Funding Scheme
X – not Funded via a specific Funding Scheme
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